Antidotes to coumarins, isoniazid, methotrexate and thyroxine, toxins that work via metabolic processes

Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions

In simple organisms like E.coli, the metabolic response to an external perturbation passes through a transient phase in which the activation of a number of latent pathways can guarantee survival at the expenses of growth. Growth is gradually recovered as the organism adapts to the new condition. This adaptation can be modeled as a process of repeated metabolic adjustments obtained through the r...

Dark Chocolate and Metabolic Syndrome; Do Polyphenols All that Matter?

Unilateral Antidotes to DNS Poisoning

We investigate defenses against DNS cache poisoning focusing on mechanisms that can be readily deployed unilaterally by the resolving organisation, preferably in a single gateway or a proxy. DNS poisoning is (still) a major threat to Internet security; determined spoofing attackers are often able to circumvent currently deployed antidotes such as port randomisation. The adoption of DNSSEC, whic...

PACT: Calculating nWoW accommodation that suits the organisations’ work processes

Workplace change and New Ways of Working (NWoW) seem to have become a fixed value in FM practice in the Netherlands today. Stimulated by new technological possibilities and maybe even by the world-wide crisis, companies are rethinking their office environments. The possibility to work anytime and anywhere seems key. However this requires a different approach to quantify the needed space and det...

Chemical toxins that cause seizures.

Seizurogenic chemicals include a variety of toxic agents, including chemical warfare agents, toxic industrial chemicals, and natural toxins. Chemical weapons such as sarin and VX, and pesticides such as parathion and carbaryl cause hyperstimulation of cholinergic receptors and an increase in excitatory neurotransmission. Glutamatergic hyperstimulation can occur after exposure to excitatory amin...